Comment by Vickash on How can I use application aliases pointing to a secondary partition and launch them via Spotlight menu?

Spotlight should index aliases but not symlinks. What you've shown is consistent with that, so the error message when trying to launch an app is puzzling. If you have Spotlight turned off for the other partition, it could be that it's seeing that the alias leads to a partition it's supposed to ignore, and then ignoring it. Try letting it index everything and see if that works.